Legacy: A Collection of Research on Regenerative Medicine
This collection of research was compiled by Regenerative Medicine pioneer Dr. Felix Linetsky, who passed away in November of 2024. Felix was passionate about maintaining the history of this field of medicine.
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by Early H. Gedny, DO
(1964) -
by Earl H. Gedney, DO
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by Earl H. Gedney, DO
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by Early H. Gedney, DO
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by Earl H. Godney, DO
(1952) -
LIGAMENT AND TENDON RELAXATION (SKELETAL DISABILITY) TREATED BY PROLOTHERAPY (FIBRO-OSSEOUS PROLIFERATION)
BY: GEORGE STUART HACKETT, M.D., F.A.C.S. (1958)
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The American Academy of Pain Medicine (2015)
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Authors: Douglas Beall, MD and Sri Nalamachu, MD (2015)
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High blood flow in painful cervical soft tissue: An ultrasound pilot study
Authors: Felix Linetsky, MD, Hatem Kalawya, Britt-Marie Stålnackeb,∗, Martin Fahlströmb, Lars Öhbergc, Håkan Alfredsone (2013)
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Authors: Felix S. Linetsky, MD; Andrea M. Trescot, MD; Laxmaiah Manchikanti, MD
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Regenerative Injection Therapy Principles and Practice
Authors: Felix S. Linetsky, Hakan Alfredson, David Crane, and Christopher J. Centeno
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Authors: Christopher J. Centeno, MD, James Elliott, MSPT, PhDc, Whitney L. Elkins, MPH, and Michael Freeman, PhD, MPH, DC
Several authors have postulated that cervical instability is a major cause of traumatic spinal pain.
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Author: Bradley D. Fullerton, MD
High-resolution ultrasound and magnetic resonance imaging to document tissue repair after prolotherapy: a report of 3 cases.
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Authors: Laxmaiah Manchikanti, MD, Jose J. Rivera, MD, Vidyasagar Pampati, MSc, Kim S. Damron, RN, Carla D. McManus, RN, BSN, Doris E. Brandon, CST, and Sue R. Wilson, ORT
Chronic, refractory low back pain and/or lower extremity is a common problem. Percutaneous adhesiolysis with hypertonic saline neurolysis was described in the management of chronic refractory low back pain and/or lower extremity, non-responsive to conservative modalities of management.
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Authors: Laxmaiah Manchikanti, MD*, Vidyasagar Pampati, MSc**, Bert Fellows, MAΩ, Jose J. Rivera, MD# , Kim S. Damron, RN##, Carla Beyer, RN##, and Kim A. Cash, RTΩ
The increasing proportion of elderly patients, coupled with increasing longevity, causes the problem of lumbosacral pain secondary to spinal stenosis of the lumbar spine to be an important issue.
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Authors: Christopher J. Centeno, MD (1,2), Dan Busse MD (1), John Kisiday, PhD (3) , Cristin Keohan (1,2), Michael Freeman, PhD(4) , and David Karli, MD(5)
The ability to repair tissue via percutaneous means may allow interventional pain physicians to manage a wide variety of diseases including peripheral joint injuries and osteoarthritis. This review will highlight the developments in cellular medicine that may soon permit interventional pain management physicians to treat a much wider variety of clinical conditions and highlight an interventional case study using these technologies.
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Authors: Felix S. Linetsky, MD*, Rafael Miguel, MD, and Francisco Torres, MD
Advances in interventional pain management have been largely based on fluoroscopically guided diagnostic and therapeutic procedures.
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Authors: Hakan Alfredson, Lars Ohberg
Chronic tendon pain: No tendinitis, but high levels of glutamate and vasculoneural ingrowth - implications for a new treatment?
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Authors: Manohar M. Panjabi, Anita Vasavada, Augustus A. White, III
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Author: Dr. Howard L. Schultheiss Jr., DPM
Concentrated platelets from the patient’s own blood, as a grafting material, has been successfully used in orthopedic surgery, maxillofacial surgery and in the wound care arena for the past several years.
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Authors: Junwei Zhang, MD,* Nobuyuki Tsuzuki, MD,* Shigeru Hirabayashi, MD,* Kunio Saiki, MD,* and Kazumasa Fujita†
A Guide for Avoiding Inadvertent Nerve Injuries During the Posterior Approach.
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Authors: Dumais R, Benoit C, Dumais A, Babin L, Bordage R, de Arcos C, Allard J, Bélanger M.
OBJECTIVE:
We assessed the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with knee osteoarthritis.
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Authors: Rabago D, Zgierska A, Fortney L, Kijowski R, Mundt M, Ryan M, Grettie J, Patterson JJ., J Altern Complement Med. 2012 Apr;18(4):408-14. doi: 10.1089/acm.2011.0030.
The objective of this study was to determine whether prolotherapy, an injection-based complementary treatment for chronic musculoskeletal conditions, improves pain, stiffness, and function in adults with symptomatic knee osteoarthritis (KOA) compared to baseline status.
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Authors: Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Pain Physician. 2008 May-Jun;11(3):343-53.
The ability to repair tissue via percutaneous means may allow interventional pain physicians to manage a wide variety of diseases including peripheral joint injuries and osteoarthritis. This review will highlight the developments in cellular medicine that may soon permit interventional pain management physicians to treat a much wider variety of clinical conditions and highlight an interventional case study using these technologies.
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Authors: Clas Linnman(1,2*), Lieuwe Appel (3) , Mats Fredrikson (1) , Torsten Gordh (4) , Anne So¨derlund (5,6), Bengt La˚ngstro¨ m (7,8), Henry Engler (9,10,11)
Abstract
There are few diagnostic tools for chronic musculoskeletal pain as structural imaging methods seldom reveal pathological
alterations. This is especially true for Whiplash Associated Disorder, for which physical signs of persistent injuries to the neck
have yet to be established. Here, we sought to visualize inflammatory processes in the neck region by means Positron
Emission Tomography using the tracer 11C-D-deprenyl, a potential marker for inflammation. Twenty-two patients with
enduring pain after a rear impact car accident (Whiplash Associated Disorder grade II) and 14 healthy controls were
investigated. Patients displayed significantly elevated tracer uptake in the neck, particularly in regions around the spineous process of the second cervical vertebra. This suggests that whiplash patients have signs of local persistent peripheral tissue inflammation, which may potentially serve as a diagnostic biomarker. The present investigation demonstrates that painful processes in the periphery can be objectively visualized and quantified with PET and that 11C-D-deprenyl is a promising tracer for these purposes.
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Authors: M Ilum Boesen, S Torp-Pedersen, M Juhl Koenig, R Christensen, H Langberg, P Ho¨lmich, M Bachmann Nielsen, H Bliddal
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Authors: Felix S. Linetsky and Frank Willard, PhD
The Pain Clinic-1999
Injecting proliferating solutions into painful areas can relieve low back pain.
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Authors: Felix S. Linetsky, M.D., Richard Derby, M.D., Rafael Miguel, M.D., Lloyd Saberski, M.D., and Michael Stanton-Hicks, M.D.
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Authors: Felix S. Linetsky, MD, Lloyd Saberski, MD, Rafael Miguel, MD and Arthur Snyder, DO
1960s-1980s
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Authors: Felix S. Linetsky, MD, Asya Mikulinsky, MD, and Larry Gorfine, MD
Part I 1930's-1950's
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Authors: HÅKAN ALFREDSON AND JILL COOK
Although Achilles—the legendary warrior and hero of Homer’s Th e Iliad—died as a result of an arrow that pierced the midportion of his tendon, today’s patient with a painful presentation in this region usually has a good long-term prognosis.
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Authors: R. A. Hauser, B.A. Woldin, E.E. Dolan, H.J. Phillips, A.C. Newlin, R.E. Moore
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Authors: Ross Hauser and Barbara Woldin
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Authors: Ross Hauser, Barbara Woldin, Danielle Steilen and Sarah Sawyer
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Publication written by David Rabago M.D., Andrew Slattengren D.O., Aleksandra Zgierska M.D.
Interest in prolotherapy among physicians and patients is high. It is becoming increasingly popular in the U.S. and internationally, and is actively used in clinical practice.
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Article by Melinda Beck featured in the March 30th, 2010 Wall Street Journal
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This article by Dr. Roy Hakala, reviews the history and scientific literature regarding prolotherapy and describes the application of the technique to treat injured or unstable temporomandibular joints (TMJ).
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In 1937, Dr. Earl Gedney wrote the first article about treatment of hypermobile knees and sacroiliac joints.
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Topol GA, Reeves KD: Regenerative injection of elite athletes with career-altering chronic groin pain who fail conservative treatment: a consecutive case series.
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Linetsky Lecture